The EGFR is a paradigm of signalling tyrosine-kinase receptors that control cell proliferation and differentiation and is rapidly internalized after ligand-binding. We are studying a novel mechanism of EGFR endocytosis that we described as controlled by PKA independently of ligand binding. It could trans-modulate the expression of empty, inactive receptors at the cell surface, and thus might provide complementary approaches for cancer therapy.
Selected References
| Author(s) | Title | Date |
|---|---|---|
| Buvinic, S. , Bravo-Zehnder, M., Boyer, J.L., Huidobro-Toro, J.P. and González, A. | “Nucleotide p2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells”. J Cell Sci 120: 4289-4301 (2007). | 0 |
| Salazar, G., González, A. | Novel Mechanism for Regulation of Epidermal Growth Factor Receptor Endocytosis Revealed by Protein Kinase A Inhibition. Mol. Biol. Cell. 13:1677-1693 (2002) | 0 |
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