In epithelial cells, the trans-Golgi network (TGN) and the endocytic route sort apical and basolateral plasma membrane proteins. We are studying the functional relationships between these pathways and adaptor proteins (AP-1B, AP-3 and AP-4), PKA and cholesterol. We are also trying to identify novel components of the TGN involved in exocytic trafficking.
Selected References
| Author(s) | Title | Date |
|---|---|---|
| Cancino, J., Torrealba, C., Bull, P., Soza, A., Yuseff, M.I., Gravotta, D., Henklein, P., Rodriguez-Boulan, E., González, A. | Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol. Biol. Cell. 2007 Dec; 18(12):4872-84. | 0 |
| Gravota, D., Deora, A., Perret, E., Oyanadel, C., Soza, A., Schreiner, R., González, A., Rodríguez-Boulan, E. | AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCKcells. Proc. Natl. Acad. Sci. USA. 104:1564-9 (2007) | 0 |
| Soza, A., Fuente, E., Norambuena, A., Henklein, P., González, A. | Sort¬ing competition with membrane-permeable peptides in intact cells revealed discrimination of transmembrane proteins not only at the trans-golgi network but also at pre-Golgi s | 0 |
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