We are interested in the intracellular traffic and function of certain members of the low-density lipoprotein receptor (LDL-R) family. These recep­tors include the low-density lipoprotein recep­tor-related protein (LRP), megalin and ApoER2, multifunctional regarding the variety of their li­gands. They can bind and mediate endocytosis of apoE and apoB bearing lipoproteins, complexes of proteases and proteinase inhibitors, complex­es of vitamins A, B12 and D with their carrier proteins, extracellular matrix proteins and other proteins such as beta-amyloid precursor protein. We are currently studying their sorting signals, exocytic and endocytic pathways and the cellu­lar machinery involved in their sorting behavior in polarized cells, using epithelial MDCK cells and neurons in primary culture as model sys­tems. We are also studying facets of their func­tions in particular pathophysiological processes.

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