Publicaciones Seleccionadas

Autor(es) Título Fecha
Gutierrez, J. and Brandan, E. A Novel Mechanism of Sequestering FGF-2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation. Mol. Cell. Biol. 30, 1634-1649. Plus Cover Photograph.(2010) 2010
Hödar C, Assar R, Colombres M, Aravena A, Pavez L, González M, Martínez S, Inestrosa NC, Maass A. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics. 2010 Jun 1;11:348. 2010
Medina WT, Laurent S, Brandan E, Aguilera JM. Uptake of tritiated liquids by individual breakfast cereal flakes. J Food Sci. 2010 Apr;75(3):E194-200. 2010
Droguett R, Cabello-Verrugio C, Santander C, Brandan E. TGF-beta receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation. Exp Cell Res. 2010 Sep 10;316(15):2487-503. Epub 2010 May 13. 2010
Ugarte G, Santander C, Brandan E. Syndecan-4 and beta1 integrin are regulated by electrical activity in skeletal muscle: Implications for cell adhesion. Matrix Biol. 2010 Jun;29(5):383-92. Epub 2010 Mar 31. 2010
Gutiérrez J, Brandan E. A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation. Mol Cell Biol. 2010 Apr;30(7):1634-49. Epub 2010 Jan 25. 2010
Cuitino L, Godoy JA, Farías GG, Couve A, Bonansco C, Fuenzalida M, Inestrosa NC. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. J Neurosci. 2010 Jun 23;30(25):8411-20. 2010
de Arce KP, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci. 2010 Mar 10;30(10):3728-38. 2010
Lazo OM, Mauna JC, Pissani CA, Inestrosa NC, Bronfman FC. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Mol Neurodegener. 2010 Jan 19;5:5. 2010
Dinamarca MC, Sagal JP, Quintanilla RA, Godoy JA, Arrázola MS, Inestrosa NC. Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Mol Neurodegener. 2010 Jan 18;5:4. 2010
Cerpa W, Farías GG, Godoy JA, Fuenzalida M, Bonansco C, Inestrosa NC. Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener. 2010 Jan 18;5:3. 2010
Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC. Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Curr Med Chem. 2010;17(5):391-406. Review. 2010
Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci. 2010 Feb;11(2):77-86. Epub 2009 Dec 16. Review. 2010
Cerpa W, Hancke JL, Morazzoni P, Bombardelli E, Riva A, Marin PP, Inestrosa NC. The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model. Curr Alzheimer Res. 2010 Mar;7(2):126-33. 2010
Parodi J, Sepúlveda FJ, Roa J, Opazo C, Inestrosa NC, Aguayo LG. Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem. 2010 Jan 22;285(4):2506-14. Epub 2009 Nov 13. 2010
Farías GG, Godoy JA, Cerpa W, Varela-Nallar L, Inestrosa NC. Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations. Dev Dyn. 2010 Jan;239(1):94-101. Review. 2010
Toledo EM, Inestrosa NC. Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Mol Psychiatry. 2010 Mar;15(3):272-85, 228. Epub 2009 Jul 21. 2010
Carvallo L, Muñoz R, Bustos F, Escobedo N, Carrasco H, Olivares G, Larraín J. Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4. J Biol Chem. 2010 Sep 17;285(38):29546-55. Epub 2010 Jul 16. 2010
Norambuena A, Metz C, Jung JE, Silva A, Otero C, Cancino J, Retamal C, Valenzuela JC, Soza A, González A. Phosphatidic acid induces ligand-independent epidermal growth factor receptor endocytic traffic through PDE4 activation. Mol Biol Cell. 2010 Aug 15;21(16):2916-29. Epub 2010 Jun 16. 2010
Norambuena A, Palma F, Poblete MI, Donoso MV, Pardo E, González A, Huidobro-Toro JP. UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an epidermal growth factor receptor-transregulated mechanism. J Biol Chem. 2010 Jan 29;285(5):2940-50. Epub 2009 Dec 7. 2010
Kenchappa RS, Tep C, Korade Z, Urra S, Bronfman FC, Yoon SO, Carter BD. p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. J Biol Chem. 2010 Jun 25;285(26):20358-68. Epub 2010 Apr 26. 2010
Lazo OM, Mauna JC, Pissani CA, Inestrosa NC, Bronfman FC. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Mol Neurodegener. 2010 Jan 19;5:5. 2010
Guillemard V, Ivanisevic L, Garcia AG, Scholten V, Lazo OM, Bronfman FC, Saragovi HU. An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors. Dev Neurobiol. 2010 Feb 15;70(3):150-64. 2010
Huidobro-Toro JP. Highlights in basic autonomic neurosciences: nucleotide receptors: molecular signalling and structural elements. Auton Neurosci. 2010 Aug 18. [Epub ahead of print] No abstract available. 2010
Colucci JA, Arita DY, Cunha TS, Di Marco GS, Vio CP, Pacheco-Silva A, Casarini DE. Renin-angiotensin system may trigger kidney damage in NOD mice. J Renin Angiotensin Aldosterone Syst. 2010 Jul 13. [Epub ahead of print] 2010
“Imatinib therapy blocks cerebellar apoptosis and improves neurological sumptoms in a mouse model of Niemann-Pick type C disease”. FASEB J. 22 / 3617-3627. 2008 Alvares AR, Klein A, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yevenes F, Bronfman FC, Sanlungo S 2008
“Lipoprotein receptors, cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer’s disease” Seminars in Cell and Developmental Biology doi:10.1016/ j.semcdb. 2008.10.005. Marzolo MP, Bu G 2007
“Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA”. Development 135(10) / 1771-80. 2008 Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyama S, Larraín J, Holt MR, Parsons M, Mayor R. 2007
Inestrosa NC, Dinamarca MC, Alvarez A. Amyloid-cholinesterase interactions. Implications for Alzheimer’s disease. FEBS J. 2008 Feb;275(4):625-32. Review. 0
Dinamarca MC, Colombres M, Cerpa W, Bonansco C, Inestrosa NC. Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway. Neurodegener Dis. 2008;5(3-4):149-52. 0
Huidobro-Toro JP, Lorca RA, Coddou C. Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors. Eur Biophys J. 2008 Mar;37(3):301-14. 0
Matus S, Burgos PV, Bravo-Zehnder M, Kraft R, Porras OH, Farías P, Barros LF, Torrealba F, Massardo L, Jacobelli, González A, Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Med. 2007 Dec 24;204 (13):3221-34. 0
Lee J, Retamal C, Cuitiño L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G. Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J Biol Chem. 2008 Apr 25;283(17):11501-8. 0
Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyama S, Larraín J, Holt MR, Parsons M, Mayor R. Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development. 2008 May;135(10):1771-80. 0
Mezzano V, Cabrera D, Vial C, Brandan E. Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2. J Cell Commun Signal. 2007 Dec;1(3-4):205-217. 0
Vial C, Zúñiga LM, Cabello-Verrugio C, Cañón P, Fadic R, Brandan E. Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation. J Cell Physiol. 2008 May;215(2):410-21. 0
Cerpa W, Dinamarca MC, Inestrosa NC. Structure-function implications in Alzheimer’s disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res. 2008 Jun;5(3):233-43. 0
Leisewitz AV, Urrutia CR, Martinez GR, Loyola G, Bronfman M. A PPARs cross-talk concertedly commits C6 glioma cells to ligodendrocytes and induces enzymes involved in myelin synthesis. J Cell Physiol. 2008 Jun 9. [Epub ahead of print] 0
Alvarez AR, Klein A, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yévenes LF, Bronfman FC, Zanlungo S. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J. 2008 Jun 30. [Epub ahead of print] 0
Colombres M, Henríquez JP, Reig GF, Scheu J, Calderón R, Alvarez A, Brandan E, Inestrosa NC. Heparin activates Wnt signaling for neuronal morphogenesis. J Cell Physiol. 2008 Sep;216(3):805-15. 0
Gravotta D, Deora A, Perret E, Oyanadel C, Soza A, Schreiner R, Gonzalez A, Rodriguez-Boulan E. AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1564-9. 0
Gatica A, Aguilera MC, Contador D, Loyola G, Pinto CO, Amigo L, Tichauer JE, Zanlungo S, Bronfman M. P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation. J Lipid Res. 2007 Apr;48(4):924-34. 0
Acuña-Castillo C, Coddou C, Bull P, Brito J, Huidobro-Toro JP. Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor. J Neurochem. 2007 Apr;101(1):17-26. 0
Cabello-Verrugio C, Brandan E. A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1. J Biol Chem. 2007 Jun 29;282(26):18842-50. 0
Fuentealba RA, Barría MI, Lee J, Cam J, Araya C, Escudero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP. ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener. 2007 Jul 9;2:14. 0
Bronfman FC, Escudero CA, Weis J, Kruttgen A. Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases. Dev Neurobiol. 2007 Aug;67(9):1183-203. Review. 0
Yuseff MI, Farfan P, Bu G, Marzolo MP. A cytoplasmic PPPSP motif determines megalin’s phosphorylation and regulates receptor’s recycling and surface expression. Traffic. 2007 Sep;8(9):1215-30. 0
Cancino J, Torrealba C, Soza A, Yuseff MI, Gravotta D, Henklein P, Rodriguez-Boulan E, González A. Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell. 2007 Dec;18(12):4872-84. 0
Coddou C, Acuña-Castillo C, Bull P, Huidobro-Toro JP. Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition. J Biol Chem. 2007 Dec 21;282(51):36879-86. 0
Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martinez G, Inestrosa NC, Bronfman M. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem. 2007 Dec 21;282(51):37006-15. 0
Bronfman FC. Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?. J Neurochem. 2007 Nov;103 Suppl 1:91-100. Review. 0
Buvinic S, Bravo-Zehnder M, Boyer JL, Huidobro-Toro JP, González A. Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. J Cell Sci. 2007 Dec 15;120(Pt 24):4289-301. 0
Gatica A., Aguilera M.C., Contador D., Loyola G., Pinto C.O., Amigo L., Tichauer J.E., Zanlungo S., Bronfman M. The cytochromes P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPAR alpha-dependent peroxisomal proliferation in isolated rat liver cells. J. Lipid Res. 2007 Apr;48(4):924-34. 0
Farias G.G., Valles A., Colombres M., Godoy J.A., Toledo E., Lukas R., Barrantes F., Inestrosa N.C. Wnt-7a Induces Presynaptic Colocalization of alfa7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons. J. Neurosci. (2007; In Press). 0
Urra M.S., Escudero C.A., Ramos P., Lisbona M.F., Allende E., Covarrubias P., Parraguez J.I., Zampieri N., Chao M.V., Annaert W., Bronfman F.C. TrkA receptor activation by NGF induces shedding of the p75 neurotrophin receptor followed by endosomal gamma -secretase-mediated release of the p75 intracellular domain. J Biol Chem. (2007). 0
Brandan E., Retamal C., Cabello-Verrugio C., Marzolo M.P. The Low density lipoprotein receptor-related protein, LRP, functions as an endocytic receptor for decorin. J. Biol. Chem 281:31562-71 (2006). 0
Buvinic S., Poblete M.I., Donoso M.V., Delpaino A.M., Briones R., Miranda R., Huidobro-Toro J.P. P2Y1 and P2Y2 receptor distribution varies along the human placental vascular tree: role of nucleotides in vascular tone regulation. J Physiol. 573: 427-43 (2006). 0
Dinamarca M.C., Cerpa W., Garrido J., Hancke J.L., Inestrosa N.C. Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer’s amyloid-beta-deposits. MOL. PSYCHIATRY. 11:1032-48 (2006). 0
Muñoz R., Moreno M., Oliva C., Orbenes C., Larraín J. Syndecan-4 regulates non-canonical Wnt signaling and is essential for convergent and extension movements in Xenopus embryos. Nat. Cell Biol, 8, 492-500 (2006). 0
Ugarte G., Brandan E. Transforming growth factor b signaling is regulated by electrical activity in skeletal muscle cells: TGF-ß type i receptor is transcriptionally up-regulated by myotube excitability. J. Biol. Chem. 28; 18473-14881 (2006). 0
Cuitino L., Matute R., Retamal C., Inestrosa N.C., Bu G., Marzolo M.P. ApoER2 is Endocytosed by a Clathrin-Mediated Process Involving the Adaptor Protein Dab2 Independent of its Rafts’ Association. Traffic 6. 9: 820-838 (2005). 0
Marzolo M.P., Bu G. Morphogens, new passengers on lipoprotein particles Current Opinion in Lipidology (2005). 0
Quintanilla R.A., Munoz F.J., Metcalfe M.J., Hitschfeld M., Olivares G., Godoy J.A., Inestrosa N.C. Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J. Biol Chem. ;280(12), 11615-25 (2005). 0
Cerpa W., Barria M.I., Chacón M., Suazo M., González M., Opazo C., Bush A.I., Inestrosa N.C. The N-Terminal Copper-Binding Domain of the Amyloid Precursor Protein Protects Against Cu2+-Neurotoxicity in vivo. FASEB J. 18, 1701-3 (2004). 0
Soza A., Fuente E., Norambuena A., Henklein P., González A. Sorting competition with membrane-permeable peptides in intact cells revealed discrimination of distinct cytosolic domains in basolateral transmembrane proteins not only at the trans-golgi network but also at pre-golgi stages. J. Biol. Chem. 279; 17376-17383 (2004). 0
Coddou C., Morales B., González J., Bull P., Garuso M., Rassendren F., Huidobro-Toro J.P. Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. J. Biol. Chem. 278: 36777-85 (2003). 0
López-Casillas F., Riquelme C., Pérez Y., Ponce-Catañeda V., Osses N., Esparaza López J., González Niñez G., Cabello Verrugio C., Mendoza V., Troncoso V., Brandan E. Betaglycan expression is transcriptionally upregulated during skeletal muscle differentiation: Modulation by MyoD and retinoic acid.J. Biol. Chem. 278: 382-390 (2003). 0
Opazo C., Huang X., Cherny R.A., Moir R.D., Roher A.E., White A.R., Cappai R., Masters C.L., Tanzi R.E., Inestrosa N.C. and Bush, A. Metalloenzyme-like activity of Alzheimer´s disease b-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol and biological reducing agents to neurotoxic H2O2. J. Biol. Chem. 277:40302-40308 (2002). 0
Osses N., Brandan E. Inhibitors of extracellular matrix formation affect skeletal muscle differentiation via a myogenin-independent mechanism Am. J. Phys. 282, C383-C394 (2002). 0
Salazar G., González A., Novel Mechanism for Regulation of Epidermal Growth Factor Receptor Endocytosis Revealed by Protein Kinase A Inhibition. Mol Biol Cell. 13:1677-1693 (2002). 0
Bravo-Zehnder M., Orio P., Norambuena A., Wallner M., Meera P., Toro L., Latorre R., and González A. Apical sorting of a voltage- and Ca2+-activated K+ channel a-subunit in MDCK cells is independent of N-glycosylation. Proc. Natl. Acad. Sci. USA 97: 13114-13119. (2000). 0
De Ferrari G.V., Inestrosa N.C. Wnt Signaling Function in Alzheimer´s Disease. Brain Res. Reviews 33: 1-12 (2000). 0
Miranda S., Opazo C., Larrondo L.F., Muñoz F.J., Ruiz F., Leighton F., Inestrosa N.C. The role of oxidative stree in the toxicity induced by amyloid b-peptide in Alzheimer´s disease. Prog. Neurobiol. 62: 633-648 (2000). 0
“Wnt - 7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons” J. BIOL. CHEM 283 / 5918-5927. 2008 Cerpa W, Godoy JA, Alfaro I, Farías G, Metcalfe MJ, Fuentealba R, Bonansco C and Inestrosa NC. 0
Amyloid-Cholinesterase interactions: Implications for Alzheimer´s Disease. FEBS JOURNAL 275 / 625 – 632. 2008 Inestrosa N.C., Dinamarca, M. and Alvarez, A 0
Beta-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway NEURODEGEN. DIS 5 / 149 – 152. 2008 Dinamarca MD, Colombres M, Cerpa W, Bonansco C and Inestrosa, 0
Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle MOL. NEUROBIOL 38 / 178 – 198. 2008 Rebolledo D, Minniti A, Grez P, Fadic R, Kohn R. and Inestrosa NC 0
“The Role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease”. MOL. NEURODEGENER 24 / 3-9. 2008 Inestrosa NC and Toledo E 0
“Circadian stress tolerance in adult Caenorhabditis elegans”. J. COMP. PHYSIOL. A NEUROTHOL SENS NEURAL BEHAV. PHYSIOL 194 / 821-828. 2008 Simonetta S, Romanowski A, Minniti A, Inestrosa NC and Golombek D 0
“Release of Acetylcholinesterase (AChE) from β-Amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice”. CHEM.BIOL. INTERACT 175 / 142-149. 2008 Dinamarca M, Arrázola M, Toledo E, Cerpa W, Hancke J and Inestrosa NC 0
“STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits”. BRAIN 131 / 2425-2442. 2008 Cancino G, Toledo E, Leal N, Hernandez D, Yévenes L, Inestrosa NC and Alvarez A 0
“Structure-function implications in ALzheimer´s disease: Effect of AB oligomers at Central Synapses”. CURR. ALZHEIMER RES. 5 / 233-243. 2008 Cerpa W, Dinamarca, M.C. and Inestrosa, N.C 0
“Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers”. J. CELL PHYSIOL 217 / 215-227. 2008 Chacón MA, Varela-Nallar L and Inestrosa NC 0
“Wnt signaling in neuroprotection and stem cell differentiation”. Progress in Neurobiology 86 / 281-296. 2008 Enrique M. Toledo, Marcela Colombres, Nibaldo C. Inestrosa 0
“Heparin Activates Wnt Signaling for Neuronal Morphogenesis”. J. CELL.. PHYSIOL 216 / 805-815. 2008 Colombres M, Henríquez JP, Reig G, Scheu J, Calderón R, Alvarez A., Brandan E and Inestrosa N.C 0
“Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy”. Matrix Biol 22 / 332-41. 2008 Brandan E, Cabello-Verrugio C, Vial C. 0
“Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-β and CTGF/CCN2”. J. Cell Commun. Signal. DOI 10.1007/s12079-008. 2008 Valeria Mezzano, Daniel Cabrera, Cecilia Vial and Enrique Brandan 0
“CTGF inhibits BMP-7 signaling in diabetic nephropathy.” J Am Soc Nephrol Nov;19(11): 2098-107. 2008 Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R. 0
“Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation”. J Cell Physiol May;215(2) 410-21. 2008 Vial C, Zúñiga LM, Cabello-Verrugio C, Cañón P, Fadic R, Brandan E. 0
“Polarized traffic of LRP1 involves AP1B and SNX17 operating upon Y-dependent sorting motifs in different pathways”. Mol Biol Cell nov-19. 2008 Donoso M., Cancino J., Lee J., van Kerhof P., Retamal C., Bu G., González A., Cáceres A., Marzolo M.P 0
“Autoantibodies agains galectin-8: Their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute immflamation Lupus”. 2008 Massardo L., Metz C., Evelin P., Mezzano V., Jarpa E., Babul M., Guzmán, A.M., Sabine, A., Kaltnerf H., Gabius H.J., González A., Soza, A 0
“A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis”. J Cell Physiol. 2 / 367-76. 2008 Leisewitz AV, Urrutia CR, Martinez GR, Loyola G, Bronfman M. 0
“Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtinexpressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease”. J Biol Chem. 283 (37) /25628-37. 2008 Quintanilla RA, Jin YN, Fuenzalida K, Bronfman M, Johnson GV 0
“Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors”. Eur Biophys J 37(3) / 301-314. 2008 Huidobro-Toro JP, Lorca RA, Coddou C 0
“P2Y1 Receptor Activation Elicits Its Partition out of Membrane Rafts and Its Rapid Internalization from Human Blood Vessels: Implications for Receptor Signaling”. Mol Pharmacol. Dec;74 / 1666-77. 2008 Dr. Alfonso González Norambuena, A., Poblete, M.I., Donoso, M.V., Espinosa, S., González, A. & Huidobro-Toro, J.P 0
“The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission” Mech Ageing 129(12) / 728-34. 2008 Donoso V., Gomez CR., Orriantia MA., Pérez V., Torres C., Coddou C., Nelson P., Maisey K., Morales B., Fernandez R., Imarai M., Huidobro-Toro JP., Sierra F. & Acuña-Castillo C. 0
“Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes”. J Biol Chem Apr 25;283(17) / 11501-8. 2008 Lee J, Retamal C, Cuitiño L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G 0
“Protein kinase D regulates trafficking of dendritic membrane proteins in developing neurons”. J Neurosci Sep 10;28(37) / 9297-308. 2008 Bisbal M, Conde C, Donoso M, Bollati F, Sesma J, Quiroga S, Díaz Añel A, Malhotra V, Marzolo MP, Cáceres A 0
Farías GG, Alfaro IE, Cerpa W, Grabowski CP, Godoy JA, Bonansco C, Inestrosa NC WNT-5a/ JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. J. BIOL. CHEM, 284, 15857-15866, 2009. 0
Suazo M, Hodar C, Morgan C, Cerpa W, Cambiazo V, Inestrosa NC, Gonzalez M. Overexpression of amyloid precursor protein increases copper content in HEK293 cells. Biochem Biophys Res Commun, 382, 740-4, 2009. 0
Vázquez M.C., Vargas L.M., Inestrosa N.C., Alvarez A.R. c-Abl modulates AICD dependent cellular responses: Transcriptional induction and apoptosis. Journal Cell Physiology, Vol 220, 136–43, 2009. 0
Minniti A.N., Rebolledo D.L., Grez P.M., Fadic R., Aldunate R., Volitakis I., Cherny R.A., Opazo C., Masters C., Bush A.I., Inestrosa N.C. Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Molecular Neurodegeneration, 4(1):2, 2009. 0
Arrázola M., Varela-Nallar L., Colombres M., Toledo E., Cruzat F., Pavez L., Assar R., Aravena A., González M., Montecinos M, Maass A., Martínez S. and Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway, Journal Cell Physiology, Vol. 221, 658–67, 2009. 0
Toledo E.M. and Inestrosa N.C. Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer’s disease, Molecular Psyquiatry, 2009. 0
Varela-Nallar L., Grabowski C., Alfaro I., Alvarez A. and Inestrosa N.C. Role of the Wnt receptor Frizzled-1 presynaptic differentiation and function, Neural Development, 4(1):41. 2009 0
Farías G., Godoy J., Cerpa W., Varela-Nallar L. and Inestrosa N.C. Wnt signaling modulates pre-and postsynaptic maturation: therapeutic considerations, Developmental Dynamics, 2009 0
Minniti A., Cataldo R., Trigo C., Vásquez L., Mujica P., Leigton F., Inestrosa N.C. and Aldunate R. Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans, Aging Cell, Vol.8, 690-705, 2009. 0
Parodi J., Sepulveda F.J., Roa J., Opazo C., Inestrosa N.C., Aguayo L.G. (beta) amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. Journal Biological Chemistry, Vol.13, 2009. 0
Inestrosa N.C. and Arenas E. Emerging roles of Wnts in the adult nervous system. NAT. REV. NEUROSCI. Nature Reviews Neuroscience (a head of print), 2009 0
Osses N., Casar J.C., Brandan E. Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism. BMC Cell Biology, Oct-73, 2009. 0
Droppelmann C.A., Gutiérrez J., Vial C., Brandan E. Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. Journal Biological Chemistry. 284(20): 13551-61, 2009. 0
Massardo L., Metz C., Evelin P., Mezzano V., Jarpa E., Babul M., Guzmán, A.M., Sabine, A., Kaltnerf H., Gabius H.J., González A., Soza, A. Autoantibodies against galectin-8: Their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Lupus, Ene-00, 539-46, 2009. 0
Norambuena A., Palma F., Poblete M.I., Donoso M.V., Pardo E., Gonzalez A., Huidobro-Toro J.P. UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an Epidermal growth factor receptor-transregulated mechanism. Journal Biological Chemistry, Dec 7, 2009. 0
Toro, A., Araya C., Córdova G., Arredondo C., Cárdenas H., Moreno R., Venegas A., Koenig C., Cancino J., Gonzalez A., and Santos M Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts. Journal Cell Biochemistry, Vol. 107, 1083-1096, 2009. 0
Gonzalez A. and Rodriguez-Boulan E. Clathrin and AP1B: Key roles in basolateral trafficking and transendosomal routes. FEBS Letters. Special Issue “The Golgi Complex”, Vol.583, 3784-3795, 2009. 0
Norambuena, A., Metz C., Vicuña L., Silva A., Pardo E., Oyanadel C., González A., Soza A. Galectin-8 induces apoptosis in jurkat t cells by phosphatidic acid-mediated erk 1/2 activation supported by PKA down regulation. Journal Biological Chemistry, Vol.284, 12670-9, 2009. 0
Coddou C., Codocedo J.F., Li S., Lillo J.G., Acuña-Castillo C., Bull P., Stojilkovic S.S., Huidobro-Toro J.P. Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430. Journal Neuroscience. 29(39):12284-91. 2009. 0
Rivas-Aravena A., Ramdohr P., Vallejos M., Valiente-Echeverría F., Dormoy-Raclet V., Rodríguez F., Pino K., Holzmann C., Huidobro-Toro J.P., Gallouzi I.E., López-Lastra M. The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites. Virology, 392(2):178-85, 2009. 0
Codocedo J.F., Rodríguez F.E., Huidobro-Toro J.P. Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions. Journal Neurochemistry, 110(2):734-44, 2009. 0
Figueroa X.F., Poblete I., Fernández R., Pedemonte C., Cortés V., Huidobro-Toro J.P. NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors. American Journal of Physiology Heart and Circulatory Physiology, 297(1): H134-43, 2009. 0
Buvinic S., Almarza G., Bustamante M., Casas M., Lopez J., Riquelme M., Saez J.C., Huidobro-Toro J.P., Jaimovich E. ATP released by electrical stimuli elicits calcium transients in skeletal muscle. Journal Biological Chemistry, Oct-12, 2009. 0
Vallejos M., Ramdohr P., Valiente-Echeverría F., Tapia K., Rodriguez F.E., Lowy F., Huidobro-Toro J.P., Dangerfield J.A., López-Lastra M. The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation. Nucleic Acids Research, Nov-04, 2009. 0
Contreras E.G., Gaete M., Sánchez N., Carrasco H., Larraín J. Early requirement of Hyaluronan for tail regeneration in Xenopus tadpoles. Development, 136(17), 2009. 0
Olivares G.H., Carrasco H., Aroca F., Carvallo L., Segovia F., Larraín J. Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development. Development Biology, 329(2): 338-49, 2009. 0
Faunes F., Sánchez N., Castellanos J., Vergara I.A., Melo F., Larraín J. Identification of novel transcripts with differential dorso-ventral expression in Xenopus gastrula using serial analysis of gene expression. Genome Biology, 11;10(2), R15. [Epub ahead of print], 2009. 0
Donoso M., Retamal D., Bu G., Lee J., Van Kerkhof P., Cancino J., Gonzalez A., Cáceres A., Marzolo M.P. Different Y-dependent signals direct basolateral sorting of LRP in the secretory and recycling pathways. Molecular Biology Cell, Jan;20(1): 481-97, 2009. 0
Marzolo M.P. and Bu G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Seminars in Cell and Developmental Biology, Apr;20(2), 191-200, 2009. 0
Cabezas F., Ramos B., Céspedes C., Vio C.P., Bronfman M. and Marzolo M.P. Megalin/LRP2 Expression is induced by peroxisome proliferator-activated receptor-alpha and –gamma: Physiopathological implications for kidney function. Kidney International, 2009. 0
Guillemard V., Ivanisevic L., Garcia A.G., Scholten V., Lazo O.M., Bronfman F.C., Saragovi H.U. An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot, and interactions with p75 co-receptors. Developmental Neurobiology, (Epub ahead of print), 2009. 0
Lazo O.M., Mauna J., Inestrosa N.I., Bronfman F.C. Retrograde Neurotrophic signalling support phenotypic differentiation but not survival of Cholinergic septal neurons. Molecular Neurodegeneration Accepted, 2009. 0