Selected Publications

Author(s) Title Date
Dinamarca MC, Colombres M, Cerpa W, Bonansco C, Inestrosa NC. Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway. Neurodegener Dis. 2008;5(3-4):149-52. 2008
Inestrosa NC, Dinamarca MC, Alvarez A. Amyloid-cholinesterase interactions. Implications for Alzheimer’s disease. FEBS J. 2008 Feb;275(4):625-32. Review. 2008
Huidobro-Toro JP, Lorca RA, Coddou C. Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors. Eur Biophys J. 2008 Mar;37(3):301-14. 2008
Matus S., Burgos P.V., Bravo-Zehnder M., Kraft R., Porras O.H., Farías P., Barros L.F., Torrealba F., Massardo L., Jacobelli, González A. Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Med. 2007 Dec 24;204 (13):3221-34. 2007
Lee J, Retamal C, Cuitiño L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G. Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J Biol Chem. 2008 Apr 25;283(17):11501-8. 0
Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyama S, Larraín J, Holt MR, Parsons M, Mayor R. Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development. 2008 May;135(10):1771-80. 0
Mezzano V, Cabrera D, Vial C, Brandan E. Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2. J Cell Commun Signal. 2007 Dec;1(3-4):205-217. 0
Vial C, Zúñiga LM, Cabello-Verrugio C, Cañón P, Fadic R, Brandan E. Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation. J Cell Physiol. 2008 May;215(2):410-21. 0
Cerpa W, Dinamarca MC, Inestrosa NC. Structure-function implications in Alzheimer’s disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res. 2008 Jun;5(3):233-43. 0
Leisewitz AV, Urrutia CR, Martinez GR, Loyola G, Bronfman M. A PPARs cross-talk concertedly commits C6 glioma cells to ligodendrocytes and induces enzymes involved in myelin synthesis. J Cell Physiol. 2008 Jun 9. [Epub ahead of print] 0
Alvarez AR, Klein A, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yévenes LF, Bronfman FC, Zanlungo S. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J. 2008 Jun 30. [Epub ahead of print] 0
Colombres M, Henríquez JP, Reig GF, Scheu J, Calderón R, Alvarez A, Brandan E, Inestrosa NC. Heparin activates Wnt signaling for neuronal morphogenesis. J Cell Physiol. 2008 Sep;216(3):805-15. 0
Gravotta D, Deora A, Perret E, Oyanadel C, Soza A, Schreiner R, Gonzalez A, Rodriguez-Boulan E. AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1564-9. 0
Gatica A, Aguilera MC, Contador D, Loyola G, Pinto CO, Amigo L, Tichauer JE, Zanlungo S, Bronfman M. The cytochromes P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPAR alpha-dependent peroxisomal proliferation in insolated rat liver cells. J Lipid Res. 2007 Apr;48(4):924-34. 0
Acuña-Castillo C, Coddou C, Bull P, Brito J, Huidobro-Toro JP. Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor. J Neurochem. 2007 Apr;101(1):17-26. 0
Cabello-Verrugio C, Brandan E. A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1. J Biol Chem. 2007 Jun 29;282(26):18842-50. 0
Fuentealba RA, Barría MI, Lee J, Cam J, Araya C, Escudero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP. ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener. 2007 Jul 9;2:14. 0
Bronfman FC, Escudero CA, Weis J, Kruttgen A. Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases. Dev Neurobiol. 2007 Aug;67(9):1183-203. Review. 0
Yuseff MI, Farfan P, Bu G, Marzolo MP. A cytoplasmic PPPSP motif determines megalin’s phosphorylation and regulates receptor’s recycling and surface expression. Traffic. 2007 Sep;8(9):1215-30. 0
Cancino J, Torrealba C, Soza A, Yuseff MI, Gravotta D, Henklein P, Rodriguez-Boulan E, González A. Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell. 2007 Dec;18(12):4872-84. 0
Coddou C, Acuña-Castillo C, Bull P, Huidobro-Toro JP. Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition. J Biol Chem. 2007 Dec 21;282(51):36879-86. 0
Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martinez G, Inestrosa NC, Bronfman M. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem. 2007 Dec 21;282(51):37006-15. 0
Bronfman FC. Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?. J Neurochem. 2007 Nov;103 Suppl 1:91-100. Review. 0
Buvinic S, Bravo-Zehnder M, Boyer JL, Huidobro-Toro JP, González A. Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. J Cell Sci. 2007 Dec 15;120(Pt 24):4289-301. 0
Farias G.G., Valles A., Colombres M., Godoy J.A., Toledo E., Lukas R., Barrantes F., Inestrosa N.C. Wnt-7a Induces Presynaptic Colocalization of alfa7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons. J. Neurosci. (2007; In Press). 0
Urra M.S., Escudero C.A., Ramos P., Lisbona M.F., Allende E., Covarrubias P., Parraguez J.I., Zampieri N., Chao M.V., Annaert W., Bronfman F.C. TrkA receptor activation by NGF induces shedding of the p75 neurotrophin receptor followed by endosomal gamma -secretase-mediated release of the p75 intracellular domain. J Biol Chem. (2007). 0
Brandan E., Retamal C., Cabello-Verrugio C., Marzolo M.P. The Low density lipoprotein receptor-related protein, LRP, functions as an endocytic receptor for decorin. J. Biol. Chem 281:31562-71 (2006). 0
Buvinic S., Poblete M.I., Donoso M.V., Delpaino A.M., Briones R., Miranda R., Huidobro-Toro J.P. P2Y1 and P2Y2 receptor distribution varies along the human placental vascular tree: role of nucleotides in vascular tone regulation. J Physiol. 573: 427-43 (2006). 0
Dinamarca M.C., Cerpa W., Garrido J., Hancke J.L., Inestrosa N.C. Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer’s amyloid-beta-deposits. MOL. PSYCHIATRY. 11:1032-48 (2006). 0
Muñoz R., Moreno M., Oliva C., Orbenes C., Larraín J. Syndecan-4 regulates non-canonical Wnt signaling and is essential for convergent and extension movements in Xenopus embryos. Nat. Cell Biol, 8, 492-500 (2006). 0
Ugarte G., Brandan E. Transforming growth factor b signaling is regulated by electrical activity in skeletal muscle cells: TGF-ß type i receptor is transcriptionally up-regulated by myotube excitability. J. Biol. Chem. 28; 18473-14881 (2006). 0
Cuitino L., Matute R., Retamal C., Inestrosa N.C., Bu G., Marzolo M.P. ApoER2 is Endocytosed by a Clathrin-Mediated Process Involving the Adaptor Protein Dab2 Independent of its Rafts’ Association. Traffic 6. 9: 820-838 (2005). 0
Marzolo M.P., Bu G. Morphogens, new passengers on lipoprotein particles Current Opinion in Lipidology (2005). 0
Quintanilla R.A., Munoz F.J., Metcalfe M.J., Hitschfeld M., Olivares G., Godoy J.A., Inestrosa N.C. Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J. Biol Chem. ;280(12), 11615-25 (2005). 0
Cerpa W., Barria M.I., Chacón M., Suazo M., González M., Opazo C., Bush A.I., Inestrosa N.C. The N-Terminal Copper-Binding Domain of the Amyloid Precursor Protein Protects Against Cu2+-Neurotoxicity in vivo. FASEB J. 18, 1701-3 (2004). 0
Soza A., Fuente E., Norambuena A., Henklein P., González A. Sorting competition with membrane-permeable peptides in intact cells revealed discrimination of distinct cytosolic domains in basolateral transmembrane proteins not only at the trans-golgi network but also at pre-golgi stages. J. Biol. Chem. 279; 17376-17383 (2004). 0
Coddou C., Morales B., González J., Bull P., Garuso M., Rassendren F., Huidobro-Toro J.P., Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. J. Biol. Chem. 278: 36777-85 (2003). 0
López-Casillas F., Riquelme C., Pérez Y., Ponce-Catañeda V., Osses N., Esparaza López J., González Niñez G., Cabello Verrugio C., Mendoza V., Troncoso V., Brandan E. Betaglycan expression is transcriptionally upregulated during skeletal muscle differentiation: Modulation by MyoD and retinoic acid.J. Biol. Chem. 278: 382-390 (2003). 0
Opazo C., Huang X., Cherny R.A., Moir R.D., Roher A.E., White A.R., Cappai R., Masters C.L., Tanzi R.E., Inestrosa N.C. and Bush, A. Metalloenzyme-like activity of Alzheimer´s disease b-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol and biological reducing agents to neurotoxic H2O2. J. Biol. Chem. 277:40302-40308 (2002). 0
Osses N., Brandan E. Inhibitors of extracellular matrix formation affect skeletal muscle differentiation via a myogenin-independent mechanism Am. J. Phys. 282, C383-C394 (2002). 0
Salazar G., González A., Novel Mechanism for Regulation of Epidermal Growth Factor Receptor Endocytosis Revealed by Protein Kinase A Inhibition. Mol Biol Cell. 13:1677-1693 (2002). 0
Bravo-Zehnder M., Orio P., Norambuena A., Wallner M., Meera P., Toro L., Latorre R., and González A. Apical sorting of a voltage- and Ca2+-activated K+ channel a-subunit in MDCK cells is independent of N-glycosylation. Proc. Natl. Acad. Sci. USA 97: 13114-13119. (2000). 0
De Ferrari G.V., Inestrosa N.C. Wnt Signaling Function in Alzheimer´s Disease. Brain Res. Reviews 33: 1-12 (2000). 0
Miranda S., Opazo C., Larrondo L.F., Muñoz F.J., Ruiz F., Leighton F., Inestrosa N.C. The role of oxidative stree in the toxicity induced by amyloid b-peptide in Alzheimer´s disease. Prog. Neurobiol. 62: 633-648 (2000). 0